To reject God’s gift of His Son, Jesus the Anointed One, is to condemn oneself to eternal death (damnation). This is simply living life in the natural while ignoring or fighting against God.
The result of such a life does not just affect one’s eternal destiny but causes one to live a life of questioning, doubt, fear, turmoil, unrest, corruption, and desperation.
Those who receive God’s gift and follow Him realize life and life more abundant in this life and life hereafter. The secret of a fulfilling and abundant life is in following Jesus and His Gospel, being not just hearers of His Word but doers of it.
This does take laying down ones life, dieing to self, and living for Him. That is yielding ones whole being to the cause and service of Christ. There is no greater joy nor more satisfying life.